Mast Cell Degranulation Mediates Compound 48/80-induced Hyperalgesia in Mice
Document Type
Article
Abstract
Mast cells mediate allergies, hypersensitivities, host defense, and venom neutralization. An area of recent interest is the contribution of mast cells to inflammatory pain. Here we found that specific, local activation of mast cells produced plantar hyperalgesia in mice. Basic secretagogue compound 48/80 induced plantar mast cell degranulation accompanied by thermal hyperalgesia, tissue edema, and neutrophil influx in the hindpaws of ND4 Swiss mice. Blocking mast cell degranulation, neutrophil extravasation, and histamine signaling abrogated these responses. Compound 48/80 also produced edema, pain, and neutrophil influx in WT C57BL/6 but not in genetically mast cell-deficient C57BL/6-Kit(W-sh)(/)(W-sh) mice. These responses were restored following plantar reconstitution with bone marrow-derived cultured mast cells.
Recommended Citation
Chatterjea, Devavani; Wetzel, Abigail; Mack, Madison; Engblom, Camilla; Allen, Juliann; Mora Solano, Carolina; Paredes, Luisa; Balsells, Evelyn; and Martinov, Tijana, "Mast Cell Degranulation Mediates Compound 48/80-induced Hyperalgesia in Mice" (2012). Faculty Publications. 12.
https://digitalcommons.macalester.edu/biofacpub/12
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Comments
Final version is published in: Biochemical and biophysical research communications; Copyright © 2012 Elsevier Inc. All rights reserved.
Read the author manuscript at the link on PubMedCentral.