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There are pronounced survival disparities by race/ethnicity in children with B-cell acute lymphoblastic leukemia (B-ALL), where Black children carry a disproportionately high risk of death, despite having some of the lowest risks of disease. While previous B-ALL studies have found these differences remain after adjustment for structural factors, the absence of statistically robust and ethically-sound methodologies has limited work on B-ALL. Using genetic ancestry — a measure of heredity that is distinct from race — we identified new risks of death and discovered genes that may help explain the disparities in B-ALL.
Barragan, Freddy Andrew, "Statistical Genetics for Pediatric Leukemia: Characterizing Racial Disparities in Pediatric Acute Lymphoblastic Leukemia" (2022). Mathematics, Statistics, and Computer Science Honors Projects. 71.
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