Document Type

Honors Project On-Campus Access Only


(chemical drawing unable to be uploaded) Azaspirene is a natural product isolated from the fungus Neosartorya sp. in 2002, wherein it was reported to be an angiogenesis inhibitor. Of particular importance in its biological activity is the fused bicyclic core, which is also the enigma that piques the interest of synthetic chemists. As chemical synthesis is as much the process of discovery along the road as it is forming the final product, the aim of this synthesis is to hopefully demonstrate a novel way of creating the fused bicycle as well as create azaspirene so that it can be used for biological testing.



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